Targeted contrast-enhanced ultrasound may have many applications in both medical diagnostics and medical therapeutics. This form of molecular imaging, known as targeted contrast-enhanced ultrasound, will only generate a strong ultrasound signal if targeted microbubbles bind in the area of interest. Targeting ligands that bind to receptors characteristic of intravascular diseases can be conjugated to microbubbles, enabling the microbubble complex to accumulate selectively in areas of interest, such as diseased or abnormal tissues. Contrast-enhanced ultrasound can be used to image blood perfusion in organs, measure blood flow rate in the heart and other organs, and for other applications. Thus, ultrasonic imaging using microbubble contrast agents enhances the ultrasound backscatter, (reflection) of the ultrasound waves, to produce a sonogram with increased contrast due to the high echogenicity difference. ![]() There is a great difference in echogenicity between the gas in the microbubbles and the soft tissue surroundings of the body. Microbubbles have a high degree of echogenicity (the ability of an object to reflect ultrasound waves). Commercially available contrast media are gas-filled microbubbles that are administered intravenously to the systemic circulation. This may be the surface of a small air bubble or a more complex structure. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. ![]() Ĭontrast-enhanced ultrasound ( CEUS) is the application of ultrasound contrast medium to traditional medical sonography. ![]() Medical imaging technique Contrast-enhanced renal ultrasonograph, showing a renal cell carcinoma successfully treated with thermal ablation, as no contrast enhancement is seen Unspecific cortical lesion on CT is confirmed cystic and benign with contrast-enhanced renal ultrasonography using image fusion.
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